Water-soluble dendrimer-poly(ethylene glycol) starlike conjugates as potential drug carriers

1999 ◽  
Vol 37 (17) ◽  
pp. 3492-3503 ◽  
Author(s):  
Mingjun Liu ◽  
Kenji Kono ◽  
Jean M. J. Fr�chet
Keyword(s):  
Ethylene Glycol ◽  
Drug Carriers ◽  
Water Soluble ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

pH-triggered poly(ethylene glycol) nanogels prepared through orthoester linkages as potential drug carriers

2018 ◽  
Vol 67 (18) ◽  
pp. 1059-1068
Author(s):  
Guanqing Yang ◽  
Shengxiang Fu ◽  
Xin Wang ◽  
Jun Wang ◽  
Rupei Tang
Keyword(s):  
Ethylene Glycol ◽  
Drug Carriers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Drug Carriers With Star Polymer Structures

2018 ◽  
pp. S293-S303 ◽  
Author(s):  
L. KOTRCHOVÁ ◽  
L. KOSTKA ◽  
T. ETRYCH
Keyword(s):  
Ethylene Glycol ◽  
Drug Carriers ◽  
Water Soluble ◽  
Star Polymer ◽  
Poly Ethylene Glycol ◽  
The Core ◽  
Polyamidoamine Dendrimers ◽  
Hydroxypropyl Methacrylamide ◽  
Poly Ethylene ◽  
Synthetic Approaches

In this review we summarize several synthetic approaches to the advanced synthesis of star-like polymer-based drug carriers. Moreover, their application as nanomedicines for therapy or the diagnosis of neoplastic diseases and their biodistribution are reviewed in detail. From a broad spectrum of star-like systems, we focus only on fully water-soluble systems, mainly based on poly(ethylene glycol) or N-(2-hydroxypropyl)methacrylamide polymer and copolymer arms and polyamidoamine dendrimers serving as the core of the star-like systems.

Synthesis of Poly(ethylene glycol) Block Copolymers as Potential Water-Soluble Drug Carriers

1995 ◽  
Vol 60 (10) ◽  
pp. 1765-1780 ◽  
Author(s):  
Michal Pechar ◽  
Jiří Strohalm ◽  
Karel Ulbrich
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Water Soluble ◽  
Poly Ethylene Glycol ◽  
Water Soluble Drug ◽  
Poly Ethylene ◽  
The Relationship

The synthesis of a model water-soluble drug carrier based on poly(ethylene glycol) (PEG) block copolymers is described. In the copolymers, two blocks of PEG are linked by a biodegradable oligopeptide or amino acid linkage containing the glutamic acid residue. 4-Nitroaniline as a drug model is attached to the γ-carboxyl group of glutamic acid of the polymer carrier via an enzymatically degradable oligopeptide spacer. The oligopeptides used were potential substrates for chymotrypsin. The relationship between the structure of oligopeptides linking two PEG blocks and the rate of chymotrypsin-catalyzed polymer chain degradation as well as the relationship between the structure of the spacer and kinetics of drug model release from the carrier after incubation in chymotrypsin solution is discussed in detail. The results showed that by modifying the structure of oligopeptides in the polymer construct, changes in the rates of both polymer degradation and the drug model release can be achieved in a very broad range.

Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24142-24153
Author(s):  
Andreea S. Voda ◽  
Kevin Magniez ◽  
Nisa V. Salim ◽  
Cynthia Wong ◽  
Qipeng Guo
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene ◽  
First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

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